To understand cancer it is necessary to explore the cellular changes that turn a normal cell into a malignant cell that repeatedly and uncontrollably divides. This transformation occurs when there is genetic damage or an alteration in the structure of a cell's DNA.
Originally developed by Perceptive Instruments and now operating as part of Instem, our genetic toxicology solutions are deployed in over 50 countries at leading universities and research institutes, as well as supporting various government programs such as those at the National Center for Toxicological Research, a Food & Drug Administration division. Our products also serve many small and medium-sized companies along with most of today’s leading multinational life sciences organizations, including all of the top 10 pharmaceutical companies worldwide.
The Comet assay, or Single-Cell Gel Electrophoresis Technique, was developed in the late 1980's by Swedish researchers Ostling & Johansson as a fast, effective way of measuring DNA strand breaks in individual cells. The Comet assay is used for a wide range of applications, including DNA damage and repair studies, genetic toxicology testing, biomonitoring and nutritional research.
Our Comet Assay IV solution allows for rapid, accurate comet scoring.
Cyto Study Manager has been designed to incorporate data acquisition and scoring systems into one package. The software transfers data straight from programs such as Comet Assay IV into the Cyto Study Manager database. All your reports can be generated from within the system and automatically combined into you final study report. Because all this is achieved within one system, there is no risk of transcription errors, no import/export, no file transfers and no copy and paste.
There are several assays used to determine the mutagenicity of a compound.
The Ames test, named after its developer Dr Bruce Ames, is the most widely used regulatory test for genotoxicity, i.e. the ability to induce mutation or cancer. Testing for genotoxicity is mandatory for pharmaceuticals, medical devices, agrochemicals and industrial chemicals. Sorcerer Colony Counter is able to automatically and effortlessly count Ames plates. The colony counter is used together with Ames Study Manager to provide efficient and accurate plate counting, data management and reporting. The Ames Study Manager has been designed to fulfil the requirements of safety assessment laboratories in pharmaceutical, medical devise and chemical companies as well as contract research organizations.
The L5178Y mouse lymphoma assay, using the thymidine kinase (tk) gene, is the most widely used in vitro mammalian cell gene mutation assay. Our Sorcerer Colony Counter is perfect for counting colonies during the soft agar mouse lymphoma assay (MLA). It counts colonies and classifies them according to size.
All our Genetic Toxicology systems have the features you need to comply with GLP guidelines and the FDA 21 CFR part 11 rule on electronic records and electronic signatures. We always supply a complete validation package including IQ, OQ and PQ assistance and all of our own project, testing and validation documentation. The data management systems include functions for reporting historical control data and archiving studies.
The Next Step…
For more than 20 years we have been helping clients around the world make the process of acquiring, managing and reporting genetox assay data as simple and secure as possible.
We invite you to review our solutions and then take that next step of contacting us today for a no-pressure practical discussion about how we can come alongside you to help streamline and accelerate your activities.